A marriage counselor collapses during a speaking engagement, but when he is put under close evaluation, the team notice changes in his behavior that conflict with his motivational message on the roles of men and women. Meanwhile, House and his Ukrainian “wife” Dominika make a deal to convince Immigration that they are a happily married couple. Also, House decides to name a team leader.

Chase takes on a patient, Moira, who is a cloistered nun on the verge of making her life-changing vows, and through the treatment process, he and Moira form a unique connection that tests their faith and reason. But when Moira’s condition worsens and requires a risky surgery, Chase’s judgment is compromised. Meanwhile, House and Taub try to remain one step ahead of each other’s pranks.

When a violent incident involving a patient has serious consequences for one staff member, House and the team are placed under review by Dr. Walter Cofield, Foreman’s former mentor and current Chief of Neurology. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team’s unconventional brand of collaboration against their ability to save lives.

The team treats an underage and homeless female patient, but when her symptoms worsen and call for an invasive surgery requiring adult consent, House and Adams argue over whether they should contact social services. The patient confesses that she ran away from home after struggling to take care of her mother, a recovering drug addict. But when her mother appears at her bedside, a more complicated relationship is revealed and the patient’s mother must put the past aside and make the best decision for her daughter. Meanwhile, Taub has a difficult time connecting with his infant daughters and House threatens to exploit Foreman’s relationship with a married woman.

A 14-year-old girl admitted for emotional issues shows worsening physical symptoms. However, House is obsessed on the case of a deceased four-year-old and will go to any lengths to solve it. Meanwhile, Park wonders why Chase is obsessed with personal grooming.

A teenage boy attempting to follow in his late father’s footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient who is convinced he is suffering from diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.

A community leader hiding dark secrets becomes ill and confesses everything… compromising his chances of receiving proper medical treatment when he antagonizes his friends and family. Meanwhile, House becomes obsessed with convincing Taub to prove that he’s the father of his two six-month-old daughters. 

House attempts to negotiate with a wealthy patient who is planning to relocate his labor force to China. Meanwhile, Foreman chairs Park’s disciplinary hearing, while Adams assesses her own ethics when she learns of their patient’s relocation plans.

When Benjamin suddenly collapses after making a rare and generous donation, House and Dr. Chi Park are convinced that his extreme altruistic behavior may indicate a deeper medical disorder. With no definitive explanation for Benjamin’s loss of consciousness and unresponsiveness to treatment, House pushes just the right buttons to recruit former prison doctor Jessica Adams to volunteer her time and expertise to the case. Benjamin then makes a bold but life-threatening offer that could save another life, and the team must diagnose his disorder before he puts his own life on the line. Meanwhile, Adams and Park test each other’s outlook on generosity and gratitude, and Thirteen’s guilt conflicts with her pursuit of personal happiness.

A surprising visitor makes House an offer he can’t refuse by giving him the opportunity to help the Princeton Plainsboro team treat a unique patient in order to save the life of an organ recipient being treated by Wilson. Although House finds himself back on familiar ground, he quickly realizes that much has changed since he left, and he is forced to work on the case with smart yet timid resident Dr. Chi Park. After several inconclusive treatments and with time running out, House and Dr. Park are left with one last option to examine the patient’s medical history that could compromise House’s conditional agreement with the hospital. Meanwhile, House makes an effort to reconnect with Wilson despite a cold reception.